ea0041gp4 | Adrenal | ECE2016
Angelousi Anna
, Georgios Kyriakopoulos
, Pavlos Constantinou
, Georgios Zografos
, Georgios Piaditis
, Theodosia Xoreutaki
, Dimitra Rontogianni
, Gregory Kaltsas
Introduction: Early detection of succinate dehydrogenase complex (SDH) mutations in patients with pheochromocytoma and paragaglioma (PPC/PGL) has important implications as it is associated with increased risk for malignancy. The use of negative immunohistochemical (IHC) staining for SDH subunit B, D, A (SDHB/-D/-A) has been proposed as an indicator of SDHs mutation and as an effective substitute for the high-cost genetic screening of all of these genes.M...